Schisandrol B
Besigomsin
CAS: 58546-54-6
Molecular Formula: C23H28O7
Schisandrol B - Names and Identifiers
| Name | Besigomsin |
| Synonyms | Gomisin A GOMISIN A Besigomsin BESIGOMISIN wuweizichunb SCHIZANDROL B SCHISANDROL B Schisandrol B schizandrol B Wuweizichun B wuweizialcoholb Wuweizi alcohol B 2,3,13-tetramethoxy-l-stereoisomer benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol,5,6,7,8-tetrahydro-6,7-dimethy |
| CAS | 58546-54-6 |
| InChI | InChI=1/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1 |
Schisandrol B - Physico-chemical Properties
| Molecular Formula | C23H28O7 |
| Molar Mass | 416.47 |
| Density | 1.1772 (rough estimate) |
| Melting Point | 88.5°C |
| Boling Point | 454.79°C (rough estimate) |
| Specific Rotation(α) | +67.9. +60.8 (c, 0.58 in CHCl3) |
| Flash Point | 304.4°C |
| Solubility | It can be chloroform, ethyl acetate, DMSO and other solvents, insoluble in water. |
| Vapor Presure | 2.79E-14mmHg at 25°C |
| Appearance | Colorless crystal |
| pKa | 14.58±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Sensitive | Sensitive to light and air |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD01941645 |
| Physical and Chemical Properties | It can be chloroform, ethyl acetate, DMSO and other solvents, insoluble in water. From Schisandra, a plant in the family Schisandra |
Schisandrol B - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
Schisandrol B - Reference
| Reference Show more | 1. Jinjinping, Wang Bo, Liu Xing, et al. Optimization of extraction process of lignans from schisandra chinensis by Box-Behnken response surface methodology [J]. Jiangsu Agricultural Sciences 2017 45(022):210-212. 2. Zhao Dawei, Wang Haobo, Li Jiali, etc. Optimization of microwave-assisted extraction of lignans from schisandra chinensis by Box-Benhnken response surface methodology [J]. Jilin agriculture 2019 447(06):52-54. 3. Jinjinping, Ai Jun, Xia Juan, et al. Content and quality evaluation of four lignans in STEM of schisandra chinensis from different germplasm resources [J]. Specialty research 2018 40(04):79-82 107. 4. Zhu Jingbo, Li, Wenyu, Xiao, Wei et al. Preparation of lignans in schisandra chinensis by two-dimensional reversed-phase liquid chromatography [J]. Chromatogram 2018 036(005):464-473. 5. Gold and silver ping, Hou Wei Gao Wei, Wang Yu Shuai, Shi Wang Yingping. Protective effect of schisandra chinensis on h_2o_2-induced oxidative stress injury in HaCaT cells [J]. Natural product research and development 2015 27(11): -1971. 6. Jinyinping, Hou, Wei, Gao, Wei, et al. Screening of antioxidant components from schisandra chinensis [J]. China Pharmacy 2016(27):2622-2625. 7. Zhang Yueyi, Zhao Yan, Liu Yonghui et al. Optimization of ultrasonic extraction of lignans from schisandra chinensis seeds [J]. Journal of Northwest Sci-Tech University of Agriculture and Forestry: natural science edition 2015(06):215-220. 8. Shangguan Mengyuan Zhao Jing Chen Junyu Yang Yanrong, Zhang Jia Yue, Zhao Shuhua. Schisandrin A enhances the pro-apoptotic effect of carboplatin on human ovarian cancer Skov3 cells and its mechanism [J]. Journal of Jilin University (Medicine edition) 2018 44(01):83-89 207. 9. Zhao Jing, Yang Yanrong, Zhang Jia Yue, Chen Junyu, Zhao Shuhua. Inhibitory effect of schisandrin A combined with carboplatin on proliferation, migration and invasion of human ovarian cancer Skov3 cells and its mechanism [J]. Journal of Jilin University (Medicine edition) 2018 44(02):292-298 465. 10. Dai Hui, Suhang, Cai Pengfei, et al. Changes of color and eight lignans of schisandra vinegar before and after steaming [J]. Chinese patent medicine 2019 41(05):1091-1096. 11. Ma, Hui, Yu, liantin, Yang, Li, Heng, et al. Purification and antioxidant activity of lignans from schisandra chinensis [J]. Chinese Journal of Traditional Chinese Medicine 2019(12). 12. Wang Guoli wishes Hong, Yan, Lin, Hai, et al. Simultaneous determination of six lignans in schisandra chinensis by Reversed-phase high performance liquid chromatography [J]. Journal of Food Safety and quality testing 2014 000(008):2470-2475. 13. Zhang Yueyi Liu Yong Hui Zhao Yan warm Cheng Ming Sheng Yanling Yang He Liu Shuangli Zhang Lianxue. Optimization of ultrasonic-assisted ethanol extraction of lignans from schisandra chinensis by response surface methodology [J]. Journal of Food Safety and quality testing 2014 5(06):1855-1861. 14. Ma, Hui, Feng, Bo, Zhu, Heyun, et al. Antioxidant and anti-inflammatory activities of total lignans from schisandra chinensis [J]. Food Research and development 2019(11). 15. Liu Jing, you Longtai, Cai Mengru, Zhang Zhiqin, Bai Jie, Yao Yu, Wu Huimin, Ni Jian. Simultaneous determination of five lignans in Xiaoer Huanglong granules by one-Test multi-evaluation method [J]. Central South pharmacy, 2021,19(03):512-516. 16. Jiao Meiyu, Yu-yue, Wu Haoxian, Kang Tingguo, Zhang Hui. Study on the mechanism and qualitative recognition model of "color discrimination and qualitative analysis" of schisandra chinensis [J]. China Pharmacy, 2020,31(24):3007-3012. 17. Liang, Dahu, et al. "HPLC-MS/MS-mediated analysis of the pharmacoid, bioavailability, and tissue distribution of schisandrol B in rats." International Journal of Analytical Chemistry 2021 (2021).https://doi.org/10.1155/2021/8862291 18. Wang, Wei, Dan-Dan Tian, and Zhang-Jin Zhang. "Clozapine Metabolism." Molecules 21.5 (2016): 597.https://doi.org/10.3390/molecules21050597 19. Zhang, Qi, et al. "Development of a matrix solid-phase dispersion extraction combined with high-performance liquid chromatography for determination of five lignans from the Schisandra chinensis." Journal of Chromatography B 1011 (2016): 151-157.https://doi 20. [IF=6.079] Hongyan Zhu et al."Sedative and hypnotic effects of supercritical carbon dioxide fluid extraction from Schisandra chinensis in mice."J Food Drug Anal. 2016 Oct;24:831 21. [IF=4.759] Huifen Ma et al."The in-capillary- 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)-sweeping micellar electrokinetic chromatography - Diode array detector method for screening and quantifying trace natural antioxidants from Schisandra chinensis."J Ch 22. [IF=4.411] Wei Wang et al."In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism."Molecules. 2016 May;21(5):597 23. [IF=4.411] Dan-Dan Tian et al."Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats."Molecules. 2016 Jun;21(6):696 24. [IF=4.545] Huimin Wu et al."Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease."Biomed Pharmacother. 2020 Jul;127:110051 25. [IF=3.935] Yunlong Guo et al."Rapid characterization of Schisandra species by using direct analysis in real time mass spectrometry."J Pharmaceut Biomed. 2021 Jan;192:113648 26. [IF=1.885] Liang Dahu et al."HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats."Int J Anal Chem. 2021;2021:8862291 27. [IF=1.618] Song Haiyan et al."Matrix Solid-Phase Dispersion Coupled with HPLC-UV for Simultaneous Extraction, Purification and Determination of Six Lignans in Schisandra chinensis Fruits."J Chromatogr Sci. 2021 Jun;: 28. [IF=4.36] Zhenghua Wu et al."Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-β signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification. |
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Product Name: Schisandrol B Visit Supplier Webpage Request for quotationCAS: 58546-54-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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